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Partial chimerism after T-cell-depleted allogeneic bone marrow transplantation in leukemic HLA-matched patients: a cytogenetic documentation
| Content Provider | Scilit |
|---|---|
| Author | Bertheas, Mf Maraninchi, D. Lafage, M. Fraisse, J. Blaise, D. Michel, G. Brizard, Cp Gaspard, Mh Novakovitch, G. |
| Copyright Year | 1988 |
| Description | We evaluated serially by cytogenetics the blood and marrow chimerism of 38 leukemic recipients of HLA-matched bone marrow transplants (BMT) who were prepared by high doses of alkylating agents and fractionated total- body irradiation (2.2 Gy X 5). Donor or host mitoses were identified by examination of sex chromosomes in 32 patients or by evaluation of the polymorphism of other chromosomes after specific banding in six patients. Twenty-four patients were recipients of untreated BMT, and 14 were recipients of T-cell-depleted BMT. In the 24 patients who received untreated BMT, all showed successful engraftment, and only three had a transient mixed chimera. In the 14 recipients of T-cell-depleted BMTs, four rejected their grafts, and seven had mixed chimeras; these mixed chimeras were more frequent in blood lymphocytes than in marrow cells and could be detected up to 26 months after BMT. This high frequency of partial chimerism after T-cell-depleted BMT by comparison with a control group suggests that the donor's T cells play an important role in the eradication of host residual hematopoiesis after allogeneic BMT. |
| Related Links | https://ashpublications.org/blood/article-pdf/72/1/89/599794/89.pdf |
| Ending Page | 93 |
| Page Count | 5 |
| Starting Page | 89 |
| DOI | 10.1182/blood.v72.1.89.89 |
| Journal | Blood |
| Issue Number | 1 |
| Volume Number | 72 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1988-07-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Bone Marrow Chromosomes Hla Transplantation Cytogenetics Donor Leukemic Cell Depleted Journal: Blood (Vol- 4, Issue- 1) |
| Content Type | Text |
| Resource Type | Article |
