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Integrin αIIbβ3 outside-in signaling
| Content Provider | Scilit |
|---|---|
| Author | Durrant, Tom N. Bosch, Marion T. Van Den Hers, Ingeborg |
| Copyright Year | 2017 |
| Description | Integrin $α_{IIb}β_{3}$ is a highly abundant heterodimeric platelet receptor that can transmit information bidirectionally across the plasma membrane, and plays a critical role in hemostasis and thrombosis. Upon platelet activation, inside-out signaling pathways increase the affinity of $α_{IIb}β_{3}$ for fibrinogen and other ligands. Ligand binding and integrin clustering subsequently stimulate outside-in signaling, which initiates and amplifies a range of cellular events driving essential platelet processes such as spreading, thrombus consolidation, and clot retraction. Integrin $α_{IIb}β_{3}$ has served as an excellent model for the study of integrin biology, and it has become clear that integrin outside-in signaling is highly complex and involves a vast array of enzymes, signaling adaptors, and cytoskeletal components. In this review, we provide a concise but comprehensive overview of $α_{IIb}β_{3}$ outside-in signaling, focusing on the key players involved, and how they cooperate to orchestrate this critical aspect of platelet biology. We also discuss gaps in the current understanding of $α_{IIb}β_{3}$ outside-in signaling and highlight avenues for future investigation. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672329/pdf |
| Ending Page | 1619 |
| Page Count | 13 |
| Starting Page | 1607 |
| DOI | 10.1182/blood-2017-03-773614 |
| Journal | Blood |
| Issue Number | 14 |
| Volume Number | 130 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2017-10-05 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Iib Platelet Critical Integrin Sub Model Biology Signaling Journal: Blood (Vol- 124, Issue- 14) |
| Content Type | Text |
| Resource Type | Article |
