NDLI: A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding

Content Provider	Scilit
Author	Stefanini, Lucia Ye, Feng Snider, Adam K. Sarabakhsh, Kasra Piatt, Raymond Paul, David S. Bergmeier, Wolfgang Petrich, Brian G.
Copyright Year	2014
Description	Key Points: Mice expressing a talin(L325R) mutant that binds to, but does not activate integrin αIIbβ3, have impaired hemostasis. Talin(W359A) reduces integrin binding, decelerates integrin activation and protects mice from thrombosis without pathological bleeding.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999757/pdf
Ending Page	2731
Page Count	10
Starting Page	2722
DOI	10.1182/blood-2013-12-543363
Journal	Blood
Issue Number	17
Volume Number	123
Language	English
Publisher	American Society of Hematology
Publisher Date	2014-04-24
Access Restriction	Open
Subject Keyword	Hematology Research and Experimental Medicine Talin Integrin Binding W359a Thrombosis L325r Hemostasis Platelets Bleeding Journal: Blood (Vol- 128, Issue- 17)
Content Type	Text
Resource Type	Article

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