Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis

Content Provider	Scilit
Author	Bossink, Aw Paemen, L. Jansen, Pm Hack, Ce Thijs, Lg Damme, J. Van
Copyright Year	1995
Description	Because of their effects on monocytes, monocyte chemotactic proteins-1 and -2 (MCP-1 and MCP-2) may participate in the pathophysiology of sepsis. We measured circulating MCP-1 and MCP-2 levels in 42 septic patients having positive local or blood cultures. MCP-1 and MCP-2 levels were elevated in 24 (57%) and 25 (59%) of 42 septic patients, respectively, compared with healthy volunteers. Both patients with gram- positive and gram-negative infections had elevated MCP-1 plasma levels (P = .0001) and P < .0001), respectively; Mann-Whitney-U test), whereas patients with gram-positive infection, but not those with gram-negative infection, had increased MCP-2 plasma levels (P= .0182). No relative differences in MCP-1 and MCP-2 plasma levels were observed between several subgroups of patients (sepsis v septic shock; survivors v nonsurvivors), although levels of MCP-1 were the highest in patients with the more severe forms of sepsis, ie, those with shock or a lethal outcome. Serial observations showed that MCP-1 and MCP-2 plasma levels remained elevated for at least 48 hours. MCP-1 correlated weakly with interleukin-8 and MCP-2, the correlations for which were most pronounced in patients with septic shock. MCP-2 correlated with interleukin-8, and surprisingly, with the complement activation product C3a; these correlations further improved when analyzing patients with septic shock or when applying gram-positive infections. Thus, our results not only show increased MCP-1 and MCP-2 levels in patients with sepsis, but also suggest that the synthesis and release of MCP-1 and MCP-2 in sepsis are differently regulated in part.
Related Links	https://ashpublications.org/blood/article-pdf/86/10/3841/616108/3841.pdf
Ending Page	3847
Page Count	7
Starting Page	3841
DOI	10.1182/blood.v86.10.3841.bloodjournal86103841
Journal	Blood
Issue Number	10
Volume Number	86
Language	English
Publisher	American Society of Hematology
Publisher Date	1995-11-15
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Sepsis Proteins Shock Monocyte Mcp Septic Patients Chemotactic Plasma Levels Journal: Blood (Vol- 112, Issue- 10)
Content Type	Text
Resource Type	Article