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Bone marrow transplants may cure patients with acute leukemia never achieving remission with chemotherapy
| Content Provider | Scilit |
|---|---|
| Author | Biggs, Jc Horowitz, Mm Gale, Rp Ash, Rc Atkinson, K. Helbig, W. Jacobsen, N. Phillips, Gl Rimm, Aa Ringden, O. |
| Copyright Year | 1992 |
| Description | About 30% of adults with acute lymphoblastic leukemia (ALL) and 20% to 40% of children and adults with acute myelogenous leukemia (AML) never achieve remission, even with intensive chemotherapy. Most die of resistant leukemia, often within 6 months or less. In this study of 126 patients with resistant ALL or AML, allogeneic bone marrow transplants from HLA-identical siblings produced remissions in 113 of 115 (98%) evaluable patients. The 3-year probability of leukemia-free survival was 21% (95% confidence interval, 15% to 29%). Leukemia-free survival was similar in ALL (23%, 12% to 40%) and AML (21%, 14% to 31%). Only 3 of 27 patients at risk relapsed more than 2 years posttransplant. |
| Related Links | https://ashpublications.org/blood/article-pdf/80/4/1090/224893/1090.pdf |
| Ending Page | 1093 |
| Page Count | 4 |
| Starting Page | 1090 |
| DOI | 10.1182/blood.v80.4.1090.bloodjournal8041090 |
| Journal | Blood |
| Issue Number | 4 |
| Volume Number | 80 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1992-08-15 |
| Access Restriction | Open |
| Subject Keyword | Hematology Research and Experimental Medicine Children Survival Bone Marrow Adults Chemotherapy Leukemia Remission Transplants Confidence Lymphoblastic Journal: Blood (Vol- 77, Issue- 4) |
| Content Type | Text |
| Resource Type | Article |
