NDLI: Treatment of Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

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Treatment of Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

Content Provider	Scilit
Author	Ottmann, Oliver G. Wassmann, Barbara
Copyright Year	2005
Description	Philadelphia chromosome positive $(Ph^{+}$) acute lymphoblastic leukemia (ALL) includes at least one-quarter of all adults with ALL. Until recently, conventional chemotherapy programs that have been effective in other precursor B-cell ALL cases have been unable to cure patients with this diagnosis. Allogeneic stem cell transplantation early in first remission has been the recommended therapy. The availability of imatinib mesylate and other tyrosine kinase inhibitors and small molecules that affect the BCR/ABL signaling pathways may be changing the treatment paradigm and the prognosis for these patients. The results from clinical trials using imatinib in the frontline setting and in relapsed patients as well as preliminary experience treating imatinib-resistant $Ph^{+}$ ALL will be described.
Related Links	http://asheducationbook.hematologylibrary.org/content/2005/1/118.full.pdf
Ending Page	122
Page Count	5
Starting Page	118
DOI	10.1182/asheducation-2005.1.118
Journal	Hematology
Issue Number	1
Volume Number	2005
Language	English
Publisher	American Society of Hematology
Publisher Date	2005-01-01
Access Restriction	Open
Subject Keyword	Cell Tissue Engineering Treatment Adults Sup Philadelphia Leukemia Chromosome Imatinib Acute Lymphoblastic Journal: Hematology (Vol- 26, Issue- 1)
Content Type	Text
Resource Type	Article

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