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Localized- and advanced-stage follicular lymphomas differ in their gene expression profiles
| Content Provider | Scilit |
|---|---|
| Author | Staiger, Annette M. Hoster, Eva Jurinovic, Vindi Winter, Stefan Leich, Ellen Kalla, Claudia Möller, Peter Bernd, Heinz-Wolfram Feller, Alfred C. Koch, Karoline Klapper, Wolfram Stein, Harald Hansmann, Martin-Leo Hartmann, Sylvia Dreyling, Martin Weigert, Oliver Hiddemann, Wolfgang Herfarth, Klaus Rosenwald, Andreas Engelhard, Marianne Ott, German Horn, Heike |
| Copyright Year | 2020 |
| Description | The genetic background of follicular lymphomas (FLs) diagnosed in advanced clinical stages III/IV, and which are frequently characterized by t(14;18), has been substantially unraveled. Molecular features, as exemplified in the clinicogenetic risk model m7FLIPI, are important tools in risk stratification. In contrast, little information is available concerning localized-stage FL (clinical stages I/II), which accounts for ∼20% of newly diagnosed FL in which the detection rate of t(14;18) is only ∼50%. To investigate the genetic background of localized-stage FL, patient cohorts with advanced-stage FL or localized-stage FL, uniformly treated within phase 3 trials of the German Low-Grade Lymphoma Study Group, were comparatively analyzed. Targeted gene expression (GE) profiling of 184 genes using nCounter technology was performed in 110 localized-stage and 556 advanced-stage FL patients. By penalized Cox regression, a prognostic GE signature could not be identified in patients with advanced-stage FL, consistent with results from global tests and univariate regression. In contrast, it was possible to define robust GE signatures discriminating localized-stage and advanced-stage FL (area under the curve, 0.98) by penalized logistic regression. Of note, 3% of samples harboring an “advanced-stage signature” in the localized-stage cohort exhibited inferior failure-free survival (hazard ratio [HR], 7.1; P = .0003). Likewise, in the advanced-stage cohort, 7% of samples with a “localized-stage signature” had prolonged failure-free survival (HR, 2.3; P = .017) and overall survival (HR, 3.4; P = .072). These data support the concept of a biological difference between localized-stage and advanced-stage FL that might contribute to the superior outcome of localized FL. |
| Related Links | https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2019000560/1223901/blood.2019000560.pdf |
| Ending Page | 190 |
| Page Count | 10 |
| Starting Page | 181 |
| DOI | 10.1182/blood.2019000560 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 135 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2020-01-16 |
| Access Restriction | Open |
| Subject Keyword | Hematology Gene Expression Survival Model Localized Fl Advanced Stage Cohort Journal: Blood (Vol- 73, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
