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Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells
| Content Provider | Scilit |
|---|---|
| Author | O’Brien, Susan Rozovski, Uri Wu, Ji Yuan Harris, David M. Liu, Zhiming Li, Ping Hazan-Halevy, Inbal Ferrajoli, Alessandra Burger, Jan A. Jain, Nitin Verstovsek, Srdan Wierda, William G. Keating, Michael J. Estrov, Zeev |
| Copyright Year | 2014 |
| Description | Key Points: Stimulation of the BCR activates JAK2 and STAT3 in CLL cells. The JAK1/2 inhibitor ruxolitinib induces apoptosis of CLL cells. |
| Related Links | https://ashpublications.org/blood/article-pdf/123/24/3797/1377180/3797.pdf |
| Ending Page | 3802 |
| Page Count | 6 |
| Starting Page | 3797 |
| DOI | 10.1182/blood-2013-10-534073 |
| Journal | Blood |
| Issue Number | 24 |
| Volume Number | 123 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2014-06-12 |
| Access Restriction | Open |
| Subject Keyword | Hematology Apoptosis Cll Cells Leukemia Jak2/stat3 Jak1/2 Lymphocytic Bcr Ruxolitinib Journal: Blood (Vol- 138, Issue- 24) |
| Content Type | Text |
| Resource Type | Article |