NDLI: A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism

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A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism

Content Provider	Scilit
Author	Tripodi, Armando Chantarangkul, Veena Martinelli, Ida Bucciarelli, Paolo Mannucci, Pier Mannuccio
Copyright Year	2004
Description	Hypercoagulability due to high coagulation factors XI, VIII, IX, II, and fibrinogen is recognized as a risk factor of venous thromboembolism (VTE). These factors are cumulatively explored by the activated partial thromboplastin time (APTT). To test the hypothesis that a short APTT increases the risk of VTE, a case-control study was carried out in 605 patients referred for thrombophilia testing after documented VTE and in 1290 controls. Median APTT ratio (coagulation time of test-to-reference plasma) values were 0.97 (range: 0.75-1.41) for patients and 1.00 (range: 0.72-1.33) for controls (P < .001). In patients who had an APTT ratio smaller than the fifth percentile of the distribution in controls, the odds ratio (OR) for VTE was 2.4 (95% confidence interval [CI]: 1.7-3.6) and was independent of inherited thrombophilic abnormalities. Further statistical analyses in 193 patients and 259 controls for whom factor VIII (FVIII) levels were available showed a decrease of the OR from 2.7 (95% CI: 1.4-5.3) to 2.1 (95% CI: 1.0-4.2), indicating that the risk was only partially mediated by high FVIII levels. In conclusion, hypercoagulability detected by a shortened APTT is independently associated with VTE. This inexpensive and simple test should be considered in the evaluation of the risk of VTE.
Related Links	http://www.bloodjournal.org/content/bloodjournal/104/12/3631.full.pdf
Ending Page	3634
Page Count	4
Starting Page	3631
DOI	10.1182/blood-2004-03-1042
Journal	Blood
Issue Number	12
Volume Number	104
Language	English
Publisher	American Society of Hematology
Publisher Date	2004-12-01
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Risk Factor Venous Thromboembolism Partial Thromboplastin Thromboplastin Time Hypercoagulability Activated Partial Vte Fibrinogen Journal: Blood (Vol- 120, Issue- 12)
Content Type	Text
Resource Type	Article

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