NDLI: High incidence of serum monoclonal Igs detected by a sensitive immunoblotting technique in B-cell chronic lymphocytic leukemia

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High incidence of serum monoclonal Igs detected by a sensitive immunoblotting technique in B-cell chronic lymphocytic leukemia

Content Provider	Scilit
Author	Beaume, A. Brizard, A. Dreyfus, B. Preud'homme, Jl
Copyright Year	1994
Description	In a prospective study in 65 untreated patients with early-stage B-cell chronic lymphocytic leukemia (B-CLL), serum monoclonal Igs (moIg) were evidenced in 80% of cases by a sensitive immunoblotting procedure. These low-abundance moIg were generally undetectable by immunoelectrophoresis and individual sera often contained several of them. Their kappa/lambda ratio was close to 1 instead of 2.8 for the lymphocyte surface Igs. A monoclonal IgM of the same light-chain type as the lymphocyte surface IgM was found in 26 sera only. The distribution of the heavy-chain classes and subclasses and light-chain types of the serum moIg was similar to those observed in aging (with a higher incidence and no correlation with age in B-CLL) and conditions with defective T-cell functions. Using a specific filter affinity- transfer assay, rheumatoid factors were detected in 58.5% of sera. However, homogeneous anti-IgG antibodies corresponding to a monoclonal IgM of the same light-chain type as the surface IgM were found in 10 patients only. These data suggest that the majority of discrete serum moIg in B-CLL are not secretion products of the leukemic clones and likely result from the immunodeficiency state inherent in the disease.
Related Links	https://ashpublications.org/blood/article-pdf/84/4/1216/230943/1216.pdf
Ending Page	1219
Page Count	4
Starting Page	1216
DOI	10.1182/blood.v84.4.1216.bloodjournal8441216
Journal	Blood
Issue Number	4
Volume Number	84
Language	English
Publisher	American Society of Hematology
Publisher Date	1994-08-15
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Antibodies Immunoblotting Functions Leukemia Lymphocytic Serum Monoclonal Lymphocyte Cll Moig Journal: Blood (Vol- 77, Issue- 4)
Content Type	Text
Resource Type	Article

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