NDLI: How I monitor long-term and late effects after blood or marrow transplantation

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How I monitor long-term and late effects after blood or marrow transplantation

Content Provider	Scilit
Author	Bhatia, Smita Armenian, Saro H. Landier, Wendy
Copyright Year	2017
Description	Blood or marrow transplantation (BMT) is used with curative intent for hematologic malignancies. Conditional on surviving the first 2 years after BMT, 5-year survival generally exceeds 70%. However, the cumulative therapeutic exposures lead to premature onset of chronic health conditions, such that the 15-year cumulative incidence of severe or life-threatening chronic health conditions exceeds 40%, resulting in premature mortality. The high burden of morbidity, coupled with a long latency between BMT and the development of chronic health conditions necessitates life-long risk-based monitoring of the BMT survivors. The issues of how and when to screen BMT survivors for therapy-related complications and exacerbation of preexisting conditions are important and largely unanswered questions. For BMT survivors, screening recommendations must incorporate risks associated with pre-BMT therapy as well as risks related to transplant conditioning and graft-versus-host disease. Here, we describe our approach to monitoring BMT survivors for risk-based screening and early detection of key late-occurring or long-term complications using patient scenarios to illustrate our discussion.
Related Links	https://ashpublications.org/blood/article-pdf/130/11/1302/1402661/blood725671.pdf
Ending Page	1314
Page Count	13
Starting Page	1302
DOI	10.1182/blood-2017-03-725671
Journal	Blood
Issue Number	11
Volume Number	130
Language	English
Publisher	American Society of Hematology
Publisher Date	2017-09-14
Access Restriction	Open
Subject Keyword	Hematology Surviving Transplantation Bmt Survivors Chronic Health Conditions Long Term Journal: Blood (Vol- 118, Issue- 11)
Content Type	Text
Resource Type	Article

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