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Increased risk of pregnancy complications in patients with essential thrombocythemia carrying the JAK2 (617V>F) mutation
| Content Provider | Scilit |
|---|---|
| Author | Passamonti, Francesco Randi, Maria Luigia Rumi, Elisa Pungolino, Ester Elena, Chiara Pietra, Daniela Scapin, Margherita Arcaini, Luca Tezza, Fabiana Moratti, Remigio Pascutto, Cristiana Fabris, Fabrizio Morra, Enrica Cazzola, Mario Lazzarino, Mario |
| Copyright Year | 2007 |
| Description | Essential thrombocythemia (ET) may occur in women of childbearing age. To investigate the risk of pregnancy complications, we studied 103 pregnancies that occurred in 62 women with ET. The 2-tailed Fisher exact test showed that pregnancy outcome was independent from that of a previous pregnancy. The rate of live birth was 64%, and 51% of pregnancies were uneventful. Maternal complications occurred in 9%, while fetal complications occurred in 40% of pregnancies. The Mantel-Haenszel method showed that fetal loss in women with ET was 3.4-fold higher (95% confidence interval [CI]: 3-3.9; P < .001) than in the general population. Half of the women studied carried the JAK2 (617V>F) mutation, and a multivariate logistic regression model identified this mutation as an independent predictor of pregnancy complications (P = .01). Neither the platelet count nor the leukocyte count was a risk factor. JAK2 (617V>F)–positive patients had an odds ratio of 2.02 (95% CI: 1.1 - 3.8) of developing complications in comparison with JAK2 (617V>F)–negative patients. Aspirin did not prevent complication in JAK2 (617V>F)–positive patients and appeared to worsen outcome in JAK2 (617V>F)–negative patients. A relationship was found between JAK2 (617V>F) and fetal loss (P = .05). This study indicates that patients carrying the JAK2 (617V>F) mutation have higher risk of developing pregnancy complications. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/110/2/485.full.pdf |
| Ending Page | 489 |
| Page Count | 5 |
| Starting Page | 485 |
| DOI | 10.1182/blood-2007-01-071068 |
| Journal | Blood |
| Issue Number | 2 |
| Volume Number | 110 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2007-07-15 |
| Access Restriction | Open |
| Subject Keyword | Hematology Model Mutation Pregnancy Complications Jak2 Loss Fetal Thrombocythemia 617v Journal: Blood (Vol- 60, Issue- 2) |
| Content Type | Text |
| Resource Type | Article |
