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Human immunodeficiency virus–driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients
| Content Provider | Scilit |
|---|---|
| Author | Weiss, Laurence Donkova-Petrini, Vladimira Caccavelli, Laure Balbo, Michèle Carbonneil, Cédric Levy, Yves |
| Copyright Year | 2004 |
| Description | The present study demonstrates that CD4+CD25+ T cells, expanded in peripheral blood of HIV-infected patients receiving highly active antiretroviral therapy (HAART), exhibit phenotypic, molecular, and functional characteristics of regulatory T cells. The majority of peripheral CD4+CD25+ T cells from HIV-infected patients expressed a memory phenotype. They were found to constitutively express transcription factor forkhead box P3 (Foxp3) messengers. CD4+CD25+ T cells weakly proliferated to immobilized anti-CD3 monoclonal antibody (mAb) and addition of soluble anti-CD28 mAb significantly increased proliferation. In contrast to CD4+CD25– T cells, CD4+CD25+ T cells from HIV-infected patients did not proliferate in response to recall antigens and to p24 protein. The proliferative capacity of CD4 T cells to tuberculin, cytomegalovirus (CMV), and p24 significantly increased following depletion of CD4+CD25+ T cells. Furthermore, addition of increasing numbers of CD4+CD25+ T cells resulted in a dose-dependent inhibition of CD4+CD25– T-cell proliferation to tuberculin and p24. CD4+CD25+ T cells responded specifically to p24 antigen stimulation by expressing transforming growth factor β (TGF-β) and interleukin 10 (IL-10), thus indicating the presence of p24-specific CD4+ T cells among the CD4+CD25+ T-cell subset. Suppressive activity was not dependent on the secretion of TGF-β or IL-10. Taken together, our results suggest that persistence of HIV antigens might trigger the expansion of CD4+CD25+ regulatory T cells, which might induce a tolerance to HIV in vivo. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/104/10/3249.full.pdf |
| Ending Page | 3256 |
| Page Count | 8 |
| Starting Page | 3249 |
| DOI | 10.1182/blood-2004-01-0365 |
| Journal | Blood |
| Issue Number | 10 |
| Volume Number | 104 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2004-11-15 |
| Access Restriction | Open |
| Subject Keyword | Virology Hiv Antigens Transcription Factor Cd25 Specific Cd4 Cd4 T Cell Expansion of Cd4 Tolerance Journal: Blood (Vol- 113, Issue- 10) |
| Content Type | Text |
| Resource Type | Article |
