NDLI: Very late relapse in diffuse large B-cell lymphoma represents clonally related disease and is marked by germinal center cell features

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Very late relapse in diffuse large B-cell lymphoma represents clonally related disease and is marked by germinal center cell features

Content Provider	Scilit
Author	Jong, Daphne De Glas, Annuska M. Boerrigter, Lucie Hermus, Marie-Christine Dalesio, Otilia Willemse, Els Nederlof, Petra M. Kersten, Marie José
Copyright Year	2003
Description	Patients with diffuse large B-cell lymphoma (DLBCL) rarely show relapse after 4 years of complete remission (CR). In this study, we addressed the following questions: (1) Does late-relapsing DLBCL represent clonally related disease or a second malignancy; and (2) is there a characteristic biologic background? In 10 of 13 DLBCL patients with relapse after 4 to 17 years, a clonal relationship was established based on identical IgH-sequences and/or identical bcl2-IgH translocation. Most (77%) showed features of germinal center (GC) cells, as defined by expression of CD10, bcl-2, and bcl-6 protein and ongoing immunoglobulin heavy chain variable region (VH) hypermutation. A GC phenotype was seen in 8 (20%) of 38 control patients matched for age, stage, and (extra)nodal localization with relapse within 2.5 years (P = .005). In conclusion, we have found evidence that late-relapsing DLBCL represents truly clonally related disease episodes in most cases and that this clinical behavior may be related to the biologic features of GC cells. (Blood. 2003;102:324-327)
Related Links	http://bloodjournal.hematologylibrary.org/content/102/1/324.full.pdf
Ending Page	327
Page Count	4
Starting Page	324
DOI	10.1182/blood-2002-09-2822
Journal	Blood
Issue Number	1
Volume Number	102
Language	English
Publisher	American Society of Hematology
Publisher Date	2003-07-01
Access Restriction	Open
Subject Keyword	Hematology Diffuse Large B Cell Lymphoma Relapse Clonally Related Represent Clonally Late Relapsing Dlbcl Germinal Center Journal: Blood (Vol- 14, Issue- 1)
Content Type	Text
Resource Type	Article

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