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Relapse cell population differs from acute onset clone as shown by absence of the initially activated N-ras oncogene in a patient with acute myelomonocytic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Senn, Hp Jiricny, J. Fopp, M. Schmid, L. Moroni, C. |
| Copyright Year | 1988 |
| Description | We have conducted a follow-up study of a patient with myelomonocytic leukemia exhibiting an N-ras mutation (Gln61----Lys61) using the polymerase chain reaction method and synthetic oligonucleotide hybridization probes. This method allowed us to detect as little as 3% of N-ras-mutated cells within a population. When the patient went into clinical remission, the mutation became undetectable. When a relapse occurred, the blasts did not carry the N-ras mutation. Analysis of M13 cloned amplified N-ras sequences from relapse DNA revealed exclusively the wild type allele of the N-ras gene. These findings suggest that the relapse cell population is derived from a different clone than the acute phase population. Furthermore, the data argue that N-ras mutation is not an initiating lesion in this case of acute myelomonocytic leukemia (AMML). |
| Related Links | https://ashpublications.org/blood/article-pdf/72/3/931/214890/931.pdf |
| Ending Page | 935 |
| Page Count | 5 |
| Starting Page | 931 |
| DOI | 10.1182/blood.v72.3.931.bloodjournal723931 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 72 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1988-09-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Clone Ras Mutation Myelomonocytic Leukemia Relapse Cell Population Journal: Blood (Vol- 67, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
