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Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation
| Content Provider | Scilit |
|---|---|
| Author | Schmidt, Janine Ramis-Zaldivar, Joan Enric Nadeu, Ferran Gonzalez-Farre, Blanca Navarro, Alba Egan, Caoimhe Montes-Mojarro, Ivonne Aidee Marafioti, Teresa Cabeçadas, Jose van der Walt, Jon Dojcinov, Stefan Rosenwald, Andreas Ott, German Bonzheim, Irina Fend, Falko Campo, Elias Jaffe, Elaine S. Salaverria, Itziar Quintanilla-Martinez, Leticia |
| Copyright Year | 2017 |
| Description | Key Points TNFRSF14 and MAP2K1 mutations are frequent in PTFL but do not occur together in the majority of cases. MAP2K1 mutations lead to activation of the downstream target phosphorylated extracellular signal-regulated kinase. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520474/pdf |
| Ending Page | 327 |
| Page Count | 5 |
| Starting Page | 323 |
| DOI | 10.1182/blood-2017-03-776278 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 130 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2017-07-20 |
| Access Restriction | Open |
| Subject Keyword | Hematology Phosphorylated Map2k1 Mutations Follicular Kinase Erk Pediatric Extracellular Lymphoma Downstream Journal: Blood (Vol- 72, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |