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Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Nadeu, Ferran Delgado, Julio Royo, Cristina Baumann, Tycho Stankovic, Tatjana Pinyol, Magda Jares, Pedro Navarro, Alba Garcia, David Martín Beà, Sílvia Salaverria, Itziar Oldreive, Ceri Aymerich, Marta Suárez-Cisneros, Helena Rozman, Maria Villamor, Neus Colomer, Dolors López-Guillermo, Armando González, Marcos Alcoceba, Miguel Terol, Maria J. Colado, Enrique Suarez-Puente, Xose López-Otín, Carlos Enjuanes, Anna Campo, Elías |
| Copyright Year | 2016 |
| Description | Key Points Clonal and subclonal mutations of NOTCH1 and TP53, clonal mutations of SF3B1, and ATM mutations in CLL have an impact on clinical outcome. Clonal evolution in longitudinal samples occurs before and after treatment and may have an unfavorable impact on overall survival. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912011/pdf |
| Ending Page | 2130 |
| Page Count | 9 |
| Starting Page | 2122 |
| DOI | 10.1182/blood-2015-07-659144 |
| Journal | Blood |
| Issue Number | 17 |
| Volume Number | 127 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2016-04-28 |
| Access Restriction | Open |
| Subject Keyword | Hematology Treatment Survival Evolution Leukemia Tp53 Lymphocytic Cll Sf3b1 Subclonal Journal: Blood (Vol- 128, Issue- 17) |
| Content Type | Text |
| Resource Type | Article |
