NDLI: Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children

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Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children

Content Provider	Scilit
Author	Baumler, Cb Bohler, T. Herr, I. Benner, A. Krammer, Ph Debatin, Km
Copyright Year	1996
Description	Increased apoptosis of CD4+ T cells is considered to be involved in CD4+ T-cell depletion in human immunodeficiency virus type-1 (HIV-1)- infected individuals progressing toward acquired immunodeficiency syndrome (AIDS). We have recently shown that CD95 (APO-1/Fas) expression is strongly increased in T cells of HIV-1-infected children. In this report we provide further evidence for a deregulated CD95 system in AIDS. CD95 expression in HIV-1+ children is not restricted to previously activated CD45RO+ T cells but is also increased on freshly isolated naive CD45RA+ T cells. In addition, specific CD95-mediated apoptosis is enhanced in both CD4+ and CD8+ T cells. Furthermore, levels of CD95 ligand mRNA are profoundly increased. Specific T-cell receptor/CD3-triggered apoptosis in HIV-1+ children is more enhanced in CD8+ than in CD4+ T cells. Accelerated activation induced cell death of T cells could partially be inhibited by blocking anti-CD95 antibody fragments. These data suggest an involvement of the CD95 receptor/ligand system in T-cell depletion and apoptosis in AIDS and may open new avenues of rational intervention strategies.
Related Links	https://ashpublications.org/blood/article-pdf/88/5/1741/623660/1741.pdf
Ending Page	1746
Page Count	6
Starting Page	1741
DOI	10.1182/blood.v88.5.1741.1741
Journal	Blood
Issue Number	5
Volume Number	88
Language	English
Publisher	American Society of Hematology
Publisher Date	1996-09-01
Access Restriction	Open
Subject Keyword	Virology Cell Death Children Apoptosis Virus Hiv Immunodeficiency Cd4 Cd8 Cd95 Cell Depletion Journal: Blood (Vol- 83, Issue- 5)
Content Type	Text
Resource Type	Article

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