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Pegylated interferon-α, ribavirin, and rituximab combined therapy of hepatitis C virus–related mixed cryoglobulinemia: a long-term study
| Content Provider | Scilit |
|---|---|
| Author | Dammacco, Franco Tucci, Felicia Anna Lauletta, Gianfranco Gatti, Pietro Re, Valli De Conteduca, Vincenza Sansonno, Silvia Russi, Sabino Mariggiò, Maria Addolorata Chironna, Maria Sansonno, Domenico Ettore |
| Copyright Year | 2010 |
| Description | This study illustrates the use and efficacy of a combination of pegylated interferon-α (Peg-IFN-α) and ribavirin (RBV), with or without rituximab (RTX), in hepatitis C virus (HCV)–related mixed cryoglobulinemia (MC). Twenty-two patients with HCV-related MC received Peg-IFN-α (2a: 180 μg or 2b: 1.5 μg/kg) weekly plus RBV (1000 or 1200 mg) daily for 48 weeks, and RTX (375 mg/m2) once a week for 1 month followed by two 5-monthly infusions (termed PIRR). Fifteen additional patients received Peg-IFN-α/RBV with the same modalities as the PIRR schedule. Complete response was achieved in 54.5% (12/22) and in 33.3% (5/15) of patients who received PIRR and Peg-IFN-α/RBV, respectively (P < .05). Clearance of HCV RNA and conversion of B-cell populations from oligoclonal to polyclonal in liver, bone marrow, and peripheral blood was maintained for up to 3 years in 10 of 12 (83.3%) and in 2 of 5 (40%) patients receiving PIRR and Peg-IFN-α/RBV, respectively (P < .01). Cryoproteins in 22.7% (5/22) of patients with PIRR and in 33.3% (5/15) with Peg-IFN-α/RBV persisted despite sustained HCV RNA clearance. No response occurred in remaining 5 patients of both groups. PIRR therapy is well tolerated and more effective than Peg-IFN-α/RBV combination in HCV-related MC. Its effect may last for more than 3 years. |
| Related Links | http://www.bloodjournal.org/content/116/3/343.full.pdf |
| Ending Page | 353 |
| Page Count | 11 |
| Starting Page | 343 |
| DOI | 10.1182/blood-2009-10-245878 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 116 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2010-07-22 |
| Access Restriction | Open |
| Subject Keyword | Gastroenterology and Hepatology Virology Efficacy Hepatitis C Virus Bone Marrow Hcv Rituximab Rbv Cryoglobulinemia Mixed Pegylated Journal: Blood (Vol- 72, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
