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A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations
| Content Provider | Scilit |
|---|---|
| Author | Yamaura, Takeshi Nakatani, Toshiyuki Uda, Ken Ogura, Hayato Shin, Wigyon Kurokawa, Naoya Saito, Koichi Fujikawa, Norie Date, Tomomi Takasaki, Masaru Terada, Daisuke Hirai, Atsushi Akashi, Akimi Chen, Fangli Adachi, Yoshiya Ishikawa, Yuichi Hayakawa, Fumihiko Hagiwara, Shinji Naoe, Tomoki Kiyoi, Hitoshi |
| Copyright Year | 2018 |
| Description | Key Points FF-10101 has selective and potent inhibitory activities against FLT3 by forming a covalent bond to the C695 residue. FF-10101 shows high efficacy against AML cells with FLT3 mutations including quizartinib-resistant activation loop mutations. |
| Related Links | https://ashpublications.org/blood/article-pdf/131/4/426/1465842/blood786657.pdf |
| Ending Page | 438 |
| Page Count | 13 |
| Starting Page | 426 |
| DOI | 10.1182/blood-2017-05-786657 |
| Journal | Blood |
| Issue Number | 4 |
| Volume Number | 131 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2018-01-25 |
| Access Restriction | Open |
| Subject Keyword | Pharmacokinetics Crystal Structure Acute Myeloid Leukemia Aml Mutations Activating Flt3 Itd Flt3 Inhibitor Journal: Blood (Vol- 79, Issue- 4) |
| Content Type | Text |
| Resource Type | Article |