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Clinical significance of soluble CD30 antigen in the sera of patients with untreated Hodgkin's disease
| Content Provider | Scilit |
|---|---|
| Author | Gause, A. Pohl, C. Tschiersch, A. Costa, L. Da Jung, W. Diehl, V. Hasenclever, D. Pfreundschuh, M. |
| Copyright Year | 1991 |
| Description | The soluble form of the CD30 antigen (sCD30), an 88-kd glycoprotein that is released by Hodgkin's-derived cell lines in vitro, can be detected in patients with Hodgkin's lymphoma, adult (HTLV-1+) T-cell leukemia, rare cases of non-Hodgkin's lymphoma, and acute infectious mononucleosis (anti-EBV-IgM+). In a prospective study of 90 consecutive untreated patients with newly diagnosed Hodgkin's disease who were treated according to the protocols of the German Hodgkin Study group, 22% had detectable levels of sCD30 in their serum. sCD30 was only detected in patients with B symptoms (20 of 44 or 45%), and maximum sCD30 levels (88 U/mL) were found in stage IVB. Of 87 patients evaluable for response, sCD30+ patients had significantly lower rates of complete remission (9 of 20 or 45% v 60 of 67 or 90%; P less than .001) and higher rates of progressive disease (9 of 20 or 45% v 6 of 67 or 9%; P less than .001) than CD30+ patients. Similarly, freedom from treatment failure curves were significantly worse for CD30+ patients (P = .0003). sCD30 disappeared after successful treatment, but increased in patients with progressive disease. It was never detected in patients in complete remission or in healthy controls. We conclude that sCD30 is a valuable marker for disease activity and has prognostic significance in Hodgkin's disease. |
| Related Links | https://ashpublications.org/blood/article-pdf/77/9/1983/221781/1983.pdf |
| Ending Page | 1988 |
| Page Count | 6 |
| Starting Page | 1983 |
| DOI | 10.1182/blood.v77.9.1983.bloodjournal7791983 |
| Journal | Blood |
| Issue Number | 9 |
| Volume Number | 77 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1991-05-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Medical Laboratory Technology Treatment Adult Lymphoma Glycoprotein Antigen Soluble Hodgkin's Scd30 Detected in Patients Journal: Blood (Vol- 107, Issue- 9) |
| Content Type | Text |
| Resource Type | Article |
