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Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice
| Content Provider | Scilit |
|---|---|
| Author | Morioka, Yoko Casari, Caterina Wohner, Nikolett Cho, Sung Yun Kurata, Sachiko Kitano, Ayumi Christophe, Olivier D. Lenting, Peter J. Li, Renhao Denis, Cécile V. Prévost, Nicolas |
| Copyright Year | 2014 |
| Description | Key Points Introduction of a disulfide bond within the A2 domain renders VWF highly thrombogenic and resistant to proteolysis. Expression of mVWF/p.S1494C-p.A1534C in mice triggers an acute onset of thrombotic thrombocytopenic purpura. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/123/21/3344.full.pdf |
| Ending Page | 3353 |
| Page Count | 10 |
| Starting Page | 3344 |
| DOI | 10.1182/blood-2013-10-531392 |
| Journal | Blood |
| Issue Number | 21 |
| Volume Number | 123 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2014-05-22 |
| Access Restriction | Open |
| Subject Keyword | Hematology Thrombocytopenia Von Willebrand Factor Anemia Mice Ttp Thrombotic Thrombocytopenic Purpura Adamts13 Disulfide Bond Proteolysis Journal: Blood (Vol- 133, Issue- 21) |
| Content Type | Text |
| Resource Type | Article |