NDLI: 14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling

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14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling

Content Provider	Scilit
Author	Chen, Yunfeng Ruggeri, Zaverio M. Du, Xiaoping
Copyright Year	2018
Description	Members of the 14-3-3 family of proteins function as adapters/modulators that recognize phosphoserine/phosphothreonine-based binding motifs in many intracellular proteins and play fundamental roles in signal transduction pathways of eukaryotic cells. In platelets, 14-3-3 plays a wide range of regulatory roles in phosphorylation-dependent signaling pathways, including G-protein signaling, cAMP signaling, agonist-induced phosphatidylserine exposure, and regulation of mitochondrial function. In particular, 14-3-3 interacts with several phosphoserine-dependent binding sites in the major platelet adhesion receptor, the glycoprotein Ib-IX complex (GPIb-IX), regulating its interaction with von Willebrand factor (VWF) and mediating VWF/GPIb-IX–dependent mechanosignal transduction, leading to platelet activation. The interaction of 14-3-3 with GPIb-IX also plays a critical role in enabling the platelet response to low concentrations of thrombin through cooperative signaling mediated by protease-activated receptors and GPIb-IX. The various functions of 14-3-3 in platelets suggest that it is a possible target for the treatment of thrombosis and inflammation.
Related Links	https://ashpublications.org/blood/article-pdf/131/22/2436/1468387/blood742650.pdf
Ending Page	2448
Page Count	13
Starting Page	2436
DOI	10.1182/blood-2017-09-742650
Journal	Blood
Issue Number	22
Volume Number	131
Language	English
Publisher	American Society of Hematology
Publisher Date	2018-05-31
Access Restriction	Open
Subject Keyword	Cell Biology Treatment Function Signaling Phosphorylation Proteins Platelet Glycoprotein Transduction Journal: Blood (Vol- 136, Issue- 22)
Content Type	Text
Resource Type	Article

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