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Low molecular weight B cell growth factor induces proliferation of human B cell precursor acute lymphoblastic leukemias
| Content Provider | Scilit |
|---|---|
| Author | Wormann, B. Mehta, Sr Maizel, Al LeBien, Tucker |
| Copyright Year | 1987 |
| Description | Experiments were conducted to determine the effect of low mol wt B cell growth factor (L-BCGF) on B cell precursor acute lymphoblastic leukemia (ALL). L-BCGF induced a significant increase in 3H-TdR incorporation in 28 of 37 bone marrow aspirates from patients with B cell precursor ALL, with stimulation indices ranging from 2 to 129. Fluorescence-activated cell sorting confirmed that in five of seven patients the common acute lymphoblastic leukemia antigen (CALLA)/CD10 positive leukemic cells were responding directly to L-BCGF. L-BCGF was capable of inducing, in some patients, an increase in absolute viable cells and could also induce colony formation in vitro. The response of B cell precursor ALL was not attributable to beta IL 1, IL 2, or gamma interferon. These results indicate that the majority of B cell precursor ALL undergo a proliferative response to L-BCGF, suggesting a regulatory role for this lymphokine in the growth of B cell precursors. |
| Related Links | https://ashpublications.org/blood/article-pdf/70/1/132/597026/132.pdf |
| Ending Page | 138 |
| Page Count | 7 |
| Starting Page | 132 |
| DOI | 10.1182/blood.v70.1.132.132 |
| Journal | Blood |
| Issue Number | 1 |
| Volume Number | 70 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1987-07-01 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry and Molecular Biology Bone Marrow Cell Growth Antigen Lymphoblastic Leukemia Viable Cell Precursor Acute Lymphoblastic Bcgf Journal: Blood (Vol- 4, Issue- 1) |
| Content Type | Text |
| Resource Type | Article |
