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Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia
| Content Provider | Scilit |
|---|---|
| Author | Imi, Tatsuya Katagiri, Takamasa Hosomichi, Kazuyoshi Zaimoku, Yoshitaka Nguyen, Viet Hoang Nakagawa, Noriharu Tajima, Atsushi Yoshizato, Tetsuichi Ogawa, Seishi Nakao, Shinji |
| Copyright Year | 2018 |
| Description | Key Points HSPCs that lack HLA class I alleles can sustain clonal hematopoiesis without driver mutations or telomere attrition in AA patients. 6pLOH may confer a survival advantage to HSPCs with age-related somatic mutations, leading to the clonal expansion of mutant HSPCs. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941997/pdf |
| Ending Page | 1012 |
| Page Count | 13 |
| Starting Page | 1000 |
| DOI | 10.1182/bloodadvances.2017013953 |
| Journal | Blood advances |
| Issue Number | 9 |
| Volume Number | 2 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2018-05-02 |
| Access Restriction | Open |
| Subject Keyword | Hematology Research and Experimental Medicine Hematopoietic Mutations Ctl Attack Hlaa Aa Patients Escaped Hspcs with Somatic Journal: Blood advances (Vol- 106, Issue- 9) |
| Content Type | Text |
| Resource Type | Article |