NDLI: bcr-abl RNA in patients with chronic myelogenous leukemia

Content Provider	Scilit
Author	Shtivelman, E. Gale, Rp Dreazen, O. Berrebi, A. Zaizov, R. Kubonishi, I. Miyoshi, I. Canaani, E.
Copyright Year	1987
Description	The major consequence of the formation of the Philadelphia (Ph1) chromosome characteristic of leukemia cells of patients with chronic myelogenous leukemia (CML) is fusion of c-abl and bcr genes. Using a sensitive RNase protection technique, we analyzed mRNA from a large number of CML patients. In most, we identified one or both species of bcr-abl chimeric transcripts. These two mRNAs vary in the specific bcr exon joined to abl exon II and are translated into slightly different proteins. The amounts of the fused mRNA within leukemia cells vary considerably between individuals and do not correlate with the phase of the disease.
Related Links	https://ashpublications.org/blood/article-pdf/69/3/971/364559/971.pdf
Ending Page	973
Page Count	3
Starting Page	971
DOI	10.1182/blood.v69.3.971.bloodjournal693971
Journal	Blood
Issue Number	3
Volume Number	69
Language	English
Publisher	American Society of Hematology
Publisher Date	1987-03-01
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Proteins Cml Leukemia Cells Exon Myelogenous Leukemia Bcr Abl Chronic Myelogenous Journal: Blood (Vol- 67, Issue- 3)
Content Type	Text
Resource Type	Article

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