Loading...
Please wait, while we are loading the content...
Similar Documents
Red blood cell associated IgG in normal and pathologic states
| Content Provider | Scilit |
|---|---|
| Author | Szymanski, Io Odgren, Pr Fortier, Nl Snyder, Lm |
| Copyright Year | 1980 |
| Description | We studied the anti-IgG-induced agglutination of both normal and abnormal red blood cells (RBC) using a sensitive, automated antiglobulin test. Normal RBC agglutinated strongly with anti-IgG antibody, indicating that IgG was present on the erythrocyte membrane. Young RBC, recovered by centrifugation from a normal RBC population, agglutinated with anti-IgG less than the old cells, suggesting that immunoglobulin G accumulated gradually on the RBC membrane in vivo. The degree of anti-IgG-induced RBC agglutination correlated negatively with the reticulocyte count and positively with the concentration of plasma IgG. RBC from patients with hypogammaglobulinemia appeared to have a low subnormal quantity of membrane-bound IgG, whereas the reverse was the case in hypergammaglobulinemia. During hemolytic episodes, RBC of patients with hereditary spherocytosis agglutinated poorly with anti- IgG, apparently due to predominance of young RBC. RBC of patients with nonspherocytic. Coombs-negative, nonimmune hemolytic anemia usually also agglutinated poorly with anti-IgG. However, in some cases of active hemolytic anemia, decreased agglutination with anti-IgG was not observed, suggesting that these young RBC had increased amounts of membrane-bound IgG. |
| Related Links | https://ashpublications.org/blood/article-pdf/55/1/48/207374/48.pdf |
| Ending Page | 54 |
| Page Count | 7 |
| Starting Page | 48 |
| DOI | 10.1182/blood.v55.1.48.bloodjournal55148 |
| Journal | Blood |
| Issue Number | 1 |
| Volume Number | 55 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1980-01-01 |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Antibody Anemia Hemolytic Anti Igg Normal Rbc Agglutinated Poorly Journal: Blood (Vol- 3, Issue- 1) |
| Content Type | Text |
| Resource Type | Article |
