NDLI: Bidirectional effects of transforming growth factor beta (TGF-beta) on colony-stimulating factor-induced human myelopoiesis in vitro: differential effects of distinct TGF-beta isoforms

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Bidirectional effects of transforming growth factor beta (TGF-beta) on colony-stimulating factor-induced human myelopoiesis in vitro: differential effects of distinct TGF-beta isoforms

Content Provider	Scilit
Author	Jacobsen, Se Keller, Jr Ruscetti, Fw Kondaiah, P. Roberts, Ab Falk, La
Copyright Year	1991
Description	Transforming growth factor-beta (TGF-beta) has potent antiproliferative effects on human hematopoietic progenitor cells. We report here that TGF-beta 1 and -beta 2 also exert bimodal dose-dependent stimulation of granulocyte-macrophage colony-stimulating factor (CSF) and granulocyte- CSF-induced day 7 granulocyte-macrophage colony-forming units. This increase in colony formation was restricted to low doses (0.01 to 1.0 ng/mL) of TGF-beta 1 and was due to increased granulopoiesis, showing that TGF-beta can affect the differentiation as well as the proliferation of hematopoietic progenitors. Furthermore, TGF-beta 3 was found to be a more potent inhibitor of hematopoietic progenitor cells than TGF-beta 1 and -beta 2. In contrast to the bidirectional proliferative effects of TGF-beta 1 and -beta 2, the effects of TGF- beta 3 on human hematopoiesis were only inhibitory, showing for the first time that TGF-beta isoforms differ not only in potencies but also with regard to the nature of the response they elicit.
Related Links	https://ashpublications.org/blood/article-pdf/78/9/2239/619605/2239.pdf
Ending Page	2247
Page Count	9
Starting Page	2239
DOI	10.1182/blood.v78.9.2239.2239
Journal	Blood
Issue Number	9
Volume Number	78
Language	English
Publisher	American Society of Hematology
Publisher Date	1991-11-01
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Toxicology Differentiation Hematopoietic Bidirectional Colony Tgf Beta Isoforms Journal: Blood (Vol- 107, Issue- 9)
Content Type	Text
Resource Type	Article

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