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DDAVP in type IIa von Willebrand's disease
| Content Provider | Scilit |
|---|---|
| Author | Gralnick, Hr Williams, Sb McKeown, Lp Rick, Me Maisonneuve, P. Jenneau, C. Sultan, Y. |
| Copyright Year | 1986 |
| Description | 1-D-Amino(8-D-arginine)-vasopressin (DDAVP) infusion in three patients with type IIa von Willebrand's disease (vWD) resulted in a normalization of the factor VIII coagulant, factor VIII-related antigen, and von Willebrand factor (vWF) (ristocetin cofactor) activities and the bleeding time. The normalization of these hemostatic parameters persisted for four hours. Over the same time period there was a marked increase in the quantity of the vWF multimers when blood was collected in the presence of protease inhibitors. The vWF multimers present were even larger than the normal. When blood was collected in the absence of protease inhibitors, a smaller increase in the plasma vWF multimers was observed and fewer of the intermediate and larger vWF multimers were seen; multimers larger than those present in normal plasma were not visualized. The platelet vWF multimers and activities did not change with or without inhibitors. These studies suggest that there is a subgroup of patients with type IIa vWD who respond to DDAVP with complete normalization of their hemostatic abnormalities and whose vWF is sensitive to proteolysis. |
| Related Links | https://ashpublications.org/blood/article-pdf/67/2/465/363232/465.pdf |
| Ending Page | 468 |
| Page Count | 4 |
| Starting Page | 465 |
| DOI | 10.1182/blood.v67.2.465.bloodjournal672465 |
| Journal | Blood |
| Issue Number | 2 |
| Volume Number | 67 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1986-02-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Protease Antigen Vwf Ddavp Von Vwd Iia Viii Multimers Willebrand's Journal: Blood (Vol- 52, Issue- 2) |
| Content Type | Text |
| Resource Type | Article |
