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Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis
| Content Provider | Scilit |
|---|---|
| Author | Skokowa, Julia Steinemann, Doris Katsman-Kuipers, Jenny E. Zeidler, Cornelia Klimenkova, Olga Klimiankou, Maksim Ünalan, Murat Kandabarau, Siarhei Makaryan, Vahagn Beekman, Renée Behrens, Kira Stocking, Carol Obenauer, Julia Schnittger, Susanne Kohlmann, Alexander Valkhof, Marijke G. Hoogenboezem, Remco Göhring, Gudrun Reinhardt, Dirk Schlegelberger, Brigitte Stanulla, Martin Vandenberghe, Peter Donadieu, Jean Zwaan, C. Michel Touw, Ivo P. Heuvel-Eibrink, Marry M. Van Den Dale, David C. Welte, Karl |
| Copyright Year | 2014 |
| Description | Key Points CN/AML patients have a high frequency of CSF3R and RUNX1 mutations. CSF3R and RUNX1 mutations induce elevated proliferation of CD34+ cells. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/123/14/2229.full.pdf |
| Ending Page | 2237 |
| Page Count | 9 |
| Starting Page | 2229 |
| DOI | 10.1182/blood-2013-11-538025 |
| Journal | Blood |
| Issue Number | 14 |
| Volume Number | 123 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2014-04-03 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Congenital Neutropenia Cd34 Leukemogenesis Cn/aml Csf3r and Runx1 Mutations Journal: Blood (Vol- 124, Issue- 14) |
| Content Type | Text |
| Resource Type | Article |