NDLI: Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B

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Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B

Content Provider	Scilit
Author	Fröhling, Stefan Schlenk, Richard F. Kayser, Sabine Morhardt, Martina Benner, Axel Döhner, Konstanze Döhner, Hartmut
Copyright Year	2006
Description	To assess the prognostic impact of cytogenetics in elderly patients with acute myeloid leukemia (AML) receiving intensive induction and consolidation treatment according to a single protocol specifically designed for patients above age 60, pretreatment samples from 361 patients registered for the AML HD98-B trial of the German-Austrian AML Study Group were analyzed by chromosome banding and fluorescence in situ hybridization, and cytogenetic findings were correlated with outcome. Using a proportional hazards model with backward selection, 3 prognostic subgroups were identified based on the influence of cytogenetic abnormalities on overall survival (OS): low-risk, t(15;17), and inv(16) in 25 of 361 patients (7%); standard-risk, normal karyotype, t(8;21), t(11q23), +8 within a noncomplex karyotype, and +11 within a noncomplex karyotype in 208 of 361 patients (58%); high-risk, all other aberrations in 128 of 361 patients (35%). On multivariate analysis, high-risk cytogenetics (hazard ratio [HR], 2.24) and age above 70 years (HR, 2.34) were independent prognostic factors affecting OS, and stratification according to these parameters demonstrated that a large subgroup of patients (55%), characterized by age 70 or older or high-risk cytogenetics, or both, had very unfavorable treatment results despite intensive chemotherapy. Thus, karyotype and age are major determinants of outcome in elderly patients with AML.
Related Links	http://www.bloodjournal.org/content/108/10/3280.full.pdf
Ending Page	3288
Page Count	9
Starting Page	3280
DOI	10.1182/blood-2006-04-014324
Journal	Blood
Issue Number	10
Volume Number	108
Language	English
Publisher	American Society of Hematology
Publisher Date	2006-11-15
Access Restriction	Open
Subject Keyword	Hematology Multivariate Analysis Treatment Cytogenetics Aml Leukemia Older Myeloid Noncomplex Hd98 Journal: Blood (Vol- 114, Issue- 10)
Content Type	Text
Resource Type	Article

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