Loading...
Please wait, while we are loading the content...
Similar Documents
Analysis of T-cell repertoire in hepatitis-associated aplastic anemia
| Content Provider | Scilit |
|---|---|
| Author | Lu, Jun Basu, Atanu Melenhorst, J. Joseph Young, Neal S. Brown, Kevin E. |
| Copyright Year | 2004 |
| Description | Hepatitis-associated aplastic anemia (HAA) is a syndrome of bone marrow failure following an acute attack of seronegative hepatitis. Clinical features and liver histology suggest a central role for an immune-mediated mechanism. To characterize the immune response, we investigated the T-cell repertoire (T-cell receptor [TCR] Vβ chain subfamily) of intrahepatic lymphocytes in HAA patients by TCR spectratyping. In 6 of 7 HAA liver samples, a broad skewing pattern in the 21 Vβ subfamilies tested was observed. In total, 62% ± 18% of HAA spectratypes showed a skewed pattern, similar to 68% ± 18% skewed spectratype patterns in 3 of 4 patients with confirmed viral hepatitis. Additionally, the T-cell repertoire had similarly low levels of complexity. In the peripheral blood lymphocytes (PBLs) of a separate group of HAA patients prior to treatment, 60% ± 15% skewed spectratypes were detected, compared with only 18% ± 8% skewed spectratypes in healthy controls. After successful immunosuppressive treatment, an apparent reversion to a normal T-cell repertoire with a corresponding significant increase in T-cell repertoire complexity was observed in the HAA samples. In conclusion, our data suggest an antigen-driven T-cell expansion in HAA and achievement of a normal T-cell repertoire during recovery from HAA. (Blood. 2004;103:4588-4593) |
| Related Links | http://www.bloodjournal.org/content/103/12/4588.full.pdf |
| Ending Page | 4593 |
| Page Count | 6 |
| Starting Page | 4588 |
| DOI | 10.1182/blood-2003-11-3959 |
| Journal | Blood |
| Issue Number | 12 |
| Volume Number | 103 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2004-06-15 |
| Access Restriction | Open |
| Subject Keyword | Hematology Treatment Bone Marrow Anemia Tcr Subfamily Haa Cell Repertoire Aplastic Journal: Blood (Vol- 120, Issue- 12) |
| Content Type | Text |
| Resource Type | Article |
