Loading...
Please wait, while we are loading the content...
Similar Documents
Comparing transplant outcomes in ALL patients after haploidentical with PTCy or matched unrelated donor transplantation
| Content Provider | Scilit |
|---|---|
| Author | Malki, Monzr M. Al Yang, Dongyun Labopin, Myriam Afanasyev, Boris Angelucci, Emanuele Bashey, Asad Socié, Gérard Karduss-Urueta, Amado Helbig, Grzegorz Bornhauser, Martin Niittyvuopio, Riitta Ganser, Arnold Ciceri, Fabio Brecht, Arne Koc, Yener Bejanyan, Nelli Ferraro, Francesca Kebriaei, Partow Mokhtari, Sally Ghobadi, Armin Nakamura, Ryotaro Forman, Stephen J. Champlin, Richard Mohty, Mohamad Ciurea, Stefan O. Nagler, Arnon |
| Copyright Year | 2020 |
| Description | We compared outcomes of 1461 adult patients with acute lymphoblastic leukemia (ALL) receiving hematopoietic cell transplantation (HCT) from a haploidentical (n = 487) or matched unrelated donor (MUD; n = 974) between January 2005 and June 2018. Graft-versus-host disease (GVHD) prophylaxis was posttransplant cyclophosphamide (PTCy), calcineurin inhibitor (CNI), and mycophenolate mofetil (MMF) for haploidentical, and CNI with MMF or methotrexate with/without antithymoglobulin for MUDs. Haploidentical recipients were matched (1:2 ratio) with MUD controls for sex, conditioning intensity, disease stage, Philadelphia-chromosome status, and cytogenetic risk. In the myeloablative setting, day +28 neutrophil recovery was similar between haploidentical (87%) and MUD (88%) (P = .11). Corresponding rates after reduced-intensity conditioning (RIC) were 84% and 88% (P = .47). The 3-month incidence of grade II-IV acute GVHD (aGVHD) and 3-year chronic GVHD (cGVHD) was similar after haploidentical compared with MUD: myeloablative conditioning, 33% vs 34% (P = .46) for aGVHD and 29% vs 31% for cGVHD (P = .58); RIC, 31% vs 30% (P = .06) for aGVHD and 24% vs 29% for cGVHD (P = .86). Among patients receiving myeloablative regimens, 3-year probabilities of overall survival were 44% and 51% with haploidentical and MUD (P = .56). Corresponding rates after RIC were 43% and 42% (P = .6). In this large multicenter case-matched retrospective analysis, despite the limitations of a registry-based study (ie, unavailability of key elements such as minimal residual disease testing), our analysis indicated that outcomes of patients with ALL undergoing HCT from a haploidentical donor were comparable with 8 of 8 MUD transplantations. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218425/pdf |
| Ending Page | 2083 |
| Page Count | 11 |
| Starting Page | 2073 |
| DOI | 10.1182/bloodadvances.2020001499 |
| Journal | Blood advances |
| Issue Number | 9 |
| Volume Number | 4 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2020-05-12 |
| Access Restriction | Open |
| Subject Keyword | Hematology Hematopoietic Prophylaxis Mmf Adult Cgvhd Haploidentical Ptcy Cni Agvhd Unrelated Journal: Blood advances (Vol- 106, Issue- 9) |
| Content Type | Text |
| Resource Type | Article |
