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Granulocyte-macrophage colony-stimulating factor (CSF) and multilineage CSF recruit human monocytes to express granulocyte CSF
| Content Provider | Scilit |
|---|---|
| Author | Oster, W. Lindemann, A. Mertelsmann, R. Herrmann, F. |
| Copyright Year | 1989 |
| Description | We assessed the capacity of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) and multilineage (Multi)-CSF to induce release of granulocyte-CSF (G-CSF) by highly purified peripheral blood monocyte (Mo) preparations. Our results reveal that GM-CSF and Multi-CSF, either alone or in a synergistic concert, activate Mo to transcribe G-CSF messenger (m) RNA and release biologically active G- CSF protein into their culture supernatants. G-CSF had no regulatory effect on Mo expression of cytoplasmic G-CSF mRNA levels and G-CSF protein secretion by itself. These differential actions of CSFs provide further insight into self-regulatory mechanisms within the growth factor hierarchy system. |
| Related Links | https://ashpublications.org/blood/article-pdf/73/1/64/217609/64.pdf |
| Ending Page | 67 |
| Page Count | 4 |
| Starting Page | 64 |
| DOI | 10.1182/blood.v73.1.64.bloodjournal73164 |
| Journal | Blood |
| Issue Number | 1 |
| Volume Number | 73 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1989-01-01 |
| Access Restriction | Open |
| Subject Keyword | Immunology Protein Macrophage Differential Csf Colony Granulocyte Stimulating Multilineage Journal: Blood (Vol- 5, Issue- 1) |
| Content Type | Text |
| Resource Type | Article |
