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Prognostic impact and targeting of CRM1 in acute myeloid leukemia
| Content Provider | Scilit |
|---|---|
| Author | Kojima, Kensuke Kornblau, Steven M. Ruvolo, Vivian Dilip, Archana Duvvuri, Seshagiri Davis, R. Eric Zhang, Min Wang, Zhiqiang Coombes, Kevin R. Zhang, Nianxiang Qiu, Yi Hua Burks, Jared K. Kantarjian, Hagop Shacham, Sharon Kauffman, Michael Andreeff, Michael |
| Copyright Year | 2013 |
| Description | Key Points High CRM1 expression was associated with short survival of AML patients. CRM1 inhibitor KPT-185 induces apoptosis mainly in a p53-dependent manner, whereas inhibition of proliferation was p53 independent. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656451/pdf |
| Ending Page | 4174 |
| Page Count | 9 |
| Starting Page | 4166 |
| DOI | 10.1182/blood-2012-08-447581 |
| Journal | Blood |
| Issue Number | 20 |
| Volume Number | 121 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2013-05-16 |
| Access Restriction | Open |
| Subject Keyword | Hematology Apoptosis Survival Proliferation Aml Leukemia Myeloid Kpt Targeting of Crm1 Crm1 in Acute Journal: Blood (Vol- 132, Issue- 20) |
| Content Type | Text |
| Resource Type | Article |