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Design and Synthesis of $mGlu_{2}$ NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core
| Content Provider | Scilit |
|---|---|
| Author | Bollinger, Katrina A. Felts, Andrew S. Brassard, Christopher J. Engers, Julie L. Rodriguez, Alice L. Weiner, Rebecca L. Cho, Hyekyung P. Chang, Sichen Bubser, Michael Jones, Carrie K. Blobaum, Anna L. Niswender, Colleen M. Conn, P. Jeffrey Emmitte, Kyle A. Lindsley, Craig W. |
| Copyright Year | 2017 |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601377/pdf |
| Ending Page | 924 |
| Page Count | 6 |
| Starting Page | 919 |
| ISSN | 19485875 |
| e-ISSN | 19485875 |
| DOI | 10.1021/acsmedchemlett.7b00279 |
| Journal | ACS Medicinal Chemistry Letters |
| Issue Number | 9 |
| Volume Number | 8 |
| Language | English |
| Publisher | American Chemical Society (ACS) |
| Publisher Date | 2017-08-18 |
| Access Restriction | Open |
| Subject Keyword | Journal: ACS Medicinal Chemistry Letters Medicinal Chemistry Cns Penetration Negative Allosteric Modulator (nam) Metabotropic Glutamate Receptor 2 (mglu2) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Biochemistry |