Loading...
Please wait, while we are loading the content...
Similar Documents
Prevention of Diabetes in Nonobese Diabetic Mice Mediated by CD1d-Restricted Nonclassical NKT Cells
| Content Provider | Scilit |
|---|---|
| Author | Duarte, Nadia Stenström, Martin Campino, Susana Bergman, Marie-Louise Lundholm, Marie Holmberg, Dan Cardell, Susanna L. |
| Copyright Year | 2004 |
| Description | A role for regulatory lymphocytes has been demonstrated in the pathogenesis of type 1 diabetes in the NOD mouse but the nature of these cells is debated. CD1d-restricted NKT lymphocytes have been implicated in this process. Previous reports of reduced diabetes incidence in NOD mice in which the numbers of NKT cells are artificially increased have been attributed to the enhanced production of IL-4 by these cells and a role for classical NKT cells, using the Vα14-Jα18 rearrangement. We now show that overexpression in NOD mice of CD1d-restricted TCR $Vα3.2^{+}Vβ9^{+}$ NKT cells producing high levels of IFN-γ but low amounts of IL-4 leads to prevention of type 1 diabetes, demonstrating a role for nonclassical CD1d-restricted NKT cells in the regulation of autoimmune diabetes. |
| Ending Page | 3118 |
| Page Count | 7 |
| Starting Page | 3112 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.173.5.3112 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/173/5/3112.full.pdf |
| Journal | The Journal of Immunology |
| Issue Number | 5 |
| Volume Number | 173 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2004-09-01 |
| Access Restriction | Open |
| Subject Keyword | Nkt Cells Cd1d Restricted Nonclassical |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
