NDLI: Helper B Cells Promote Cytotoxic T Cell Survival and Proliferation Independently of Antigen Presentation through CD27/CD70 Interactions

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Helper B Cells Promote Cytotoxic T Cell Survival and Proliferation Independently of Antigen Presentation through CD27/CD70 Interactions

Content Provider	Scilit
Author	Deola, Sara Panelli, Monica C. Maric, Dragan Selleri, Silvia Dmitrieva, Natalia I. Voss, Ching Y. Klein, Harvey Stroncek, David Wang, Ena Marincola, Francesco M.
Copyright Year	2008
Description	CD8-expressing cytotoxic T cell (CTL) interactions with APCs and helper T cells determine their function and ability to survive. In this study, we describe a novel interaction independent of Ag presentation between activated CTLs and bystander CD19-expressing B lymphocytes. Ag-stimulated CTLs serially engage autologous B lymphocytes through CD27/CD70 contact that promotes their survival and proliferation. Moreover, these interactions induce the release of proinflammatory cytokines that follows two general patterns: 1) an epitope-dependent enhancement of cytokine release, and 2) a previously undiscovered coordinate release of cytokines independent of epitope exposure. The latter includes chemoattractants targeting activated T cells. As a result, activated T cells are attracted to B cells, which exert a “helper” role in lymphatic organs or in areas of inflammation. This observation provides a mechanistic explanation to previously reported experimental observations suggesting that B cells are required for T cell priming in vivo.
Ending Page	1372
Page Count	11
Starting Page	1362
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.180.3.1362
Alternate Webpage(s)	http://www.jimmunol.org/content/180/3/1362.full.pdf
Journal	The Journal of Immunology
Issue Number	3
Volume Number	180
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-02-01
Access Restriction	Open
Subject Keyword	Cd27/cd70
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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