Loading...
Please wait, while we are loading the content...
Similar Documents
Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis
| Content Provider | Scilit |
|---|---|
| Author | Tonel, Giulia Conrad, Curdin Laggner, Ute Meglio, Paola Di Grys, Katarzyna McClanahan, Terrill K. Blumenschein, Wendy M. Qin, Jian-Zhong Xin, Hong Oldham, Elizabeth Kastelein, Robert Nickoloff, Brian J. Nestle, Frank O. |
| Copyright Year | 2010 |
| Description | Interleukin-23 is a key cytokine involved in the generation of Th17 effector cells. Clinical efficacy of an anti-p40 mAb blocking both IL-12 and IL-23 and disease association with single nucleotide polymorphisms in the IL23R gene raise the question of a functional role of IL-23 in psoriasis. In this study, we provide a comprehensive analysis of IL-23 and its receptor in psoriasis and demonstrate its functional importance in a disease-relevant model system. The expression of IL-23 and its receptor was increased in the tissues of patients with psoriasis. Injection of a mAb specifically neutralizing human IL-23 showed IL-23–dependent inhibition of psoriasis development comparable to the use of anti-TNF blockers in a clinically relevant xenotransplant mouse model of psoriasis. Together, our results identify a critical functional role for IL-23 in psoriasis and provide the rationale for new treatment strategies in chronic epithelial inflammatory disorders. |
| Ending Page | 5691 |
| Page Count | 4 |
| Starting Page | 5688 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1001538 |
| Journal | The Journal of Immunology |
| Issue Number | 10 |
| Volume Number | 185 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2010-11-15 |
| Access Restriction | Open |
| Subject Keyword | Critical Functional Role |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
