NDLI: Cutting Edge: Perforin Down-Regulates CD4 and CD8 T Cell-Mediated Immune Responses to a Transplanted Organ

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Cutting Edge: Perforin Down-Regulates CD4 and CD8 T Cell-Mediated Immune Responses to a Transplanted Organ

Content Provider	Scilit
Author	Bose, Anirban Inoue, Yoshihiko Kokko, Kenneth E. Lakkis, Fadi G.
Copyright Year	2003
Description	Perforin mediates target cell apoptosis by CTLs and NK cells. Although perforin expression correlates strongly with acute allograft rejection, perforin-deficient mice reject allografts with the same kinetics as wild-type recipients. In this study, we tested the hypothesis that while perforin is dispensable for acute rejection, it is essential for down-regulating the alloimmune response by inducing the apoptosis of host immune cells. Using a skin transplantation model, we found that perforin-deficient mice are resistant to the induction of allograft acceptance by agents that block T cell costimulation. Failure to induce allograft acceptance in these mice was observed irrespective of whether the alloimmune response was CD4 or CD8 T cell-mediated and could be attributed to defective apoptosis of activated CD4 and CD8 T cells. In contrast, perforin did not influence T cell proliferation. Therefore, perforin is an essential immunoregulatory molecule that may be required for the induction of transplantation tolerance.
Ending Page	1614
Page Count	4
Starting Page	1611
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.170.4.1611
Journal	The Journal of Immunology
Issue Number	4
Volume Number	170
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2003-02-15
Access Restriction	Open
Subject Keyword	Cd8 T Cell Mediated
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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