NDLI: CD8+ T Lymphocytes in Double αβ TCR Transgenic Mice. II. Competitive Fitness of Dual αβ TCR CD8+ T Lymphocytes in the Peripheral Pools

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CD8+ T Lymphocytes in Double αβ TCR Transgenic Mice. II. Competitive Fitness of Dual αβ TCR CD8+ T Lymphocytes in the Peripheral Pools

Content Provider	Scilit
Author	Legrand, Nicolas Freitas, Antonio A.
Copyright Year	2001
Description	We studied Rag2-deficient mice bearing two rearranged αβ TCR transgenes, both restricted to the MHC H-2Db class I molecule. We have previously shown that, in these DTg mice, most peripheral CD8 T cells express one TCRβ chain associated with two TCRα chains, as in one-third of the mature T cells from normal mice. We examined the functional behavior of the dual-receptor CD8 T cells developing either in the absence or in the presence of self-Ag. The dual-receptor CD8 T cells, which develop in absence of self-Ag, show efficient responses to immunization and remain sensitive to induction of peripheral tolerance. In contrast to single TCR T cells, the dual-TCR cells, when tolerized upon exposure to high levels of self-Ag, are not deleted and therefore may exert important regulatory functions. When developing in the presence of self-Ag, the dual-receptor-expressing CD8 T cells escape central deletion, but are not fully competent to respond to cognate stimuli. Overall, we found that the dual-TCR CD8 T cells show a poor competitive value and can be out-competed by single-TCR cells, both in the course of immune responses and in reconstitution experiments. The decreased fitness of the dual-receptor cells may contribute to diminishing the autoimmune hazard that they could represent.
Ending Page	6164
Page Count	7
Starting Page	6158
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.167.11.6158
Journal	The Journal of Immunology
Issue Number	11
Volume Number	167
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2001-12-01
Access Restriction	Open
Subject Keyword	Dual Receptor Tcr Cd8
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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