NDLI: Infrequent Detection of HIV-1-Specific, But Not Cytomegalovirus-Specific, CD8+ T Cell Responses in Young HIV-1-Infected Infants

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Infrequent Detection of HIV-1-Specific, But Not Cytomegalovirus-Specific, CD8+ T Cell Responses in Young HIV-1-Infected Infants

Content Provider	Scilit
Author	Scott, Zachary A. Chadwick, Ellen G. Gibson, Laura L. Catalina, Michelle D. McManus, Margaret M. Yogev, Ram Palumbo, Paul Sullivan, John L. Britto, Paula Gay, Hannah Luzuriaga, Katherine Investigators, PACTG 345
Copyright Year	2001
Description	Early potent combination antiretroviral therapies (ART) for HIV-1 infection can preserve or restore immune function, but control of viral replication early in infection may interfere with the development of HIV-1-specific immune responses. Using an IFN-γ ELISPOT assay, we evaluated the breadth and intensity of HIV-1-specific $CD8^{+}$ T cell responses in 17 vertically infected infants who began ART at 1–23 mo of age. CMV-specific responses were also characterized in three infants coinfected with HIV-1 and CMV. Before ART, HIV-1-specific $CD8^{+}$ T cell responses were detected in two of 13 (15%) infants 6 mo of age and became persistently undetectable in only one child. CMV-specific $CD8^{+}$ T cell responses were persistently detected in all HIV-1 and CMV coinfected infants. In conclusion, HIV-1-specific $CD8^{+}$ T cell responses were less commonly detected before therapy in young infants than in older infants. Suppression of viral replication appeared to interfere with the development and maintenance of HIV-1-specific $CD8^{+}$ T cell responses. The detection of CMV-specific responses in HIV-1 and CMV coinfected infants suggests a selective defect in the generation or maintenance of HIV-1-specific $CD8^{+}$ T cell responses. Therapeutic HIV-1 vaccine strategies in young infants may prolong the clinical benefit of ART by expanding the HIV-1-specific $CD8^{+}$ T cell pool.
Ending Page	7140
Page Count	7
Starting Page	7134
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.167.12.7134
Journal	The Journal of Immunology
Issue Number	12
Volume Number	167
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2001-12-15
Access Restriction	Open
Subject Keyword	Viral Replication Cell Responses
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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