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Invariant NKT Cells Are Required for Antitumor Responses Induced by Host-Versus-Graft Responses
| Content Provider | Scilit |
|---|---|
| Author | Saito, Toshiki I. Li, Hao Wei Sykes, Megan |
| Copyright Year | 2010 |
| Description | Based on clinical observations, we have previously shown in a murine model that recipient leukocyte infusion (RLI) induces a host-versus-graft reaction in mixed bone marrow chimeras and that rejection of donor cells leads to a specific antitumor response against recipient malignancies. This response is dependent on T cells and IFN-γ. We investigated the role of NKT cells (NKTs) in this phenomenon. Depletion of recipient $NK1.1^{+}$ cells led to loss of an anti-tumor effect induced by RLI in mixed bone marrow chimeras. In recipients specifically lacking host invariant NKT cells (iNKTs), RLI did not induce an antitumor effect, indicating a critical role for recipient iNKTs. Conversely, specific activation of iNKTs enhanced the anti-tumor effect induced by RLI. Following RLI, recipient iNKTs, NK cells, dendritic cells (DCs), and CD8 T cells were activated. CD8 T cells were the major producers of IFN-γ. Lack of recipient iNKTs resulted in failure of activation of NK cells and DCs by RLI. Our studies demonstrate a central role for iNKTs in promoting RLI-induced anti-tumor effects and suggest that this pathway involved promotion of the activation of recipient NK cells and DCs. |
| Ending Page | 2105 |
| Page Count | 7 |
| Starting Page | 2099 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.0901985 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/185/4/2099.full.pdf |
| Journal | The Journal of Immunology |
| Issue Number | 4 |
| Volume Number | 185 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2010-08-15 |
| Access Restriction | Open |
| Subject Keyword | Bone Marrow |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
