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Cutting Edge: Antigen Presentation to CD8 T Cells after Influenza A Virus Infection
| Content Provider | Scilit |
|---|---|
| Author | Ingulli, Elizabeth Funatake, Castle Jacovetty, Erica L. Zanetti, Maurizio |
| Copyright Year | 2009 |
| Description | Influenza A virus infection induces massive inflammation and lung damage. Activation of CD8 T cells by dendritic cells (DCs) is necessary to control disease. We undertook studies to track directly Ag presentation to CD8 T cells in vivo through the first 72 h after infection with OVA-expressing influenza A virus. We found that Ag presentation by DCs occurs strictly in the draining lymph nodes and not within the lung itself. Surprisingly, Ag presentation was found to be mediated by a $CD11b^{+}$ DC population. Finally, the expression of antigenic complexes on DCs correlated with the location and timing of CD8 T cell activation. These results have implications for approaches to control influenza A virus infection. |
| Ending Page | 33 |
| Page Count | 5 |
| Starting Page | 29 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.182.1.29 |
| Journal | The Journal of Immunology |
| Issue Number | 1 |
| Volume Number | 182 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2009-01-01 |
| Access Restriction | Open |
| Subject Keyword | Activation of Cd8 T Cells Influenza A Virus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
