NDLI: Toll-Like Receptor 4 Dependence of Innate and Adaptive Immunity to Salmonella: Importance of the Kupffer Cell Network

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Toll-Like Receptor 4 Dependence of Innate and Adaptive Immunity to Salmonella: Importance of the Kupffer Cell Network

Content Provider	Scilit
Author	Vazquez-Torres, Andrés Vallance, Bruce A. Bergman, Molly A. Finlay, B. Brett Cookson, Brad T. Jones-Carson, Jessica Fang, Ferric C.
Copyright Year	2004
Description	Mammalian cells recognize LPS from Gram-negative bacteria via the Toll-like receptor 4 (TLR4) complex. During experimental Salmonella infection, C3H/HeJ mice carrying a dominant-negative mutation in TLR4 exhibited delayed chemokine production, impaired NO generation, and attenuated cellular immune responses. However, dramatically enhanced bacterial growth within the Kupffer cell network before the recruitment of inflammatory cells appeared to be primarily responsible for the early demise of Salmonella-infected TLR4-deficient mice. LPS-TLR4 signaling plays an essential role in the generation of both innate and adaptive immune responses throughout the course of infection with Gram-negative bacteria. Alternative pattern-recognition receptors cannot completely compensate for the loss of TLR4, and compensation occurs at the expense of an increased microbial burden.
Ending Page	6208
Page Count	7
Starting Page	6202
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.172.10.6202
Alternate Webpage(s)	http://www.jimmunol.org/content/jimmunol/172/10/6202.full.pdf
Journal	The Journal of Immunology
Issue Number	10
Volume Number	172
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2004-05-15
Access Restriction	Open
Subject Keyword	Gram Negative Bacteria Adaptive Immunity Innate and Adaptive
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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