NDLI: Coordinated Expression of Ig-Like Inhibitory MHC Class I Receptors and Acquisition of Cytotoxic Function in Human CD8+ T Cells

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Coordinated Expression of Ig-Like Inhibitory MHC Class I Receptors and Acquisition of Cytotoxic Function in Human CD8+ T Cells

Content Provider	Scilit
Author	Anfossi, Nicolas Doisne, Jean-Marc Peyrat, Marie-Alix Ugolini, Sophie Bonnaud, Olivia Bossy, David Pitard, Vincent Merville, Pierre Moreau, Jean-François Delfraissy, Jean-François Dechanet-Merville, Julie Bonneville, Marc Venet, Alain Vivier, Eric
Copyright Year	2004
Description	MHC class I-specific inhibitory receptors are expressed by a subset of memory-phenotype $CD8^{+}$ T cells. Similar to NK cells, MHC class I-specific inhibitory receptors might subserve on T cells an important negative control that participates to the prevention of autologous damage. We analyzed here human $CD8^{+}$ T cells that express the Ig-like MHC class I-specific inhibitory receptors: killer cell Ig-like receptor (KIR) and CD85j. The cell surface expression of Ig-like inhibitory MHC class I receptors was found to correlate with an advanced stage of $CD8^{+}$ T cell maturation as evidenced by the reduced proliferative potential of $KIR^{+}$ and $CD85j^{+}$ T cells associated with their high intracytoplasmic perforin content. This concomitant regulation might represent a safety mechanism to control potentially harmful cytolytic $CD8^{+}$ T cells, by raising their activation threshold. Yet, $KIR^{+}$ and $CD85j^{+}$ T cells present distinct features. $KIR^{+}CD8^{+}$ T cells are poor IFN-γ producers upon TCR engagement. In addition, KIR are barely detectable at the surface of virus-specific T cells during the course of CMV or HIV-1 infection. By contrast, $CD85j^{+}CD8^{+}$ T cells produce IFN-γ upon TCR triggering, and represent a large fraction of virus-specific T cells. Thus, the cell surface expression of Ig-like inhibitory MHC class I receptors is associated with T cell engagement into various stages of the cytolytic differentiation pathway, and the cell surface expression of CD85j or KIR witnesses to the history of qualitatively and/or quantitatively distinct T cell activation events.
Ending Page	7229
Page Count	7
Starting Page	7223
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.173.12.7223
Alternate Webpage(s)	http://www.jimmunol.org/content/173/12/7223.full.pdf
Journal	The Journal of Immunology
Issue Number	12
Volume Number	173
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2004-12-15
Access Restriction	Open
Subject Keyword	Mhc Class
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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