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CD8+ Myelin Peptide-Specific T Cells Can Chemoattract CD4+ Myelin Peptide-Specific T Cells: Importance of IFN-Inducible Protein 10
| Content Provider | Scilit |
|---|---|
| Author | Biddison, William E. Cruikshank, William W. Pelfrey, Clara M. Taub, Dennis D. Turner, Richard V. |
| Copyright Year | 1998 |
| Description | The demyelination process that occurs in the central nervous system (CNS) of patients with multiple sclerosis (MS) is due, in part, to an inflammatory response in which $CD4^{+}$ and $CD8^{+}$ T cells and macrophages infiltrate white matter. While it is thought that the inflammatory and demyelination process in MS is the product of Th1-associated cytokines secreted by $CD4^{+}$ myelin protein-specific T cells present in the CNS, the mechanisms that are responsible for the recruitment and maintenance of these myelin-reactive $CD4^{+}$ T cells in the CNS have not been elucidated. We have shown previously that $CD8^{+}$CTL that recognize peptides derived from sequences of the myelin proteolipid protein (PLP) presented by HLA class I molecules can be generated in vitro, and that these PLP-specific $CD8^{+}$CTL secrete the proinflammatory chemokines macrophage-inflammatory protein-1α and -1β, IL-16, and IP-10. In this study, we demonstrate that soluble products of these PLP-specific $CD8^{+}$CTL can chemoattract $CD4^{+}$ T cells that are specific for a myelin basic protein peptide and a PLP peptide, and that the majority of this chemotactic activity is mediated by IFN-inducible protein 10. These results demonstrate that PLP-specific $CD8^{+}$ T cells can play a role in the recruitment and retention of myelin-derived peptide-specific $CD4^{+}$ T cells, and indicate that they may play a proinflammatory role in the pathogenesis of MS. |
| Ending Page | 448 |
| Page Count | 5 |
| Starting Page | 444 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.160.1.444 |
| Journal | The Journal of Immunology |
| Issue Number | 1 |
| Volume Number | 160 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 1998-01-01 |
| Access Restriction | Open |
| Subject Keyword | Specific T Cells Chemoattract Cd4 Ifn Inducible Protein |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
