NDLI: A Role for NF-κB Subunits p50 and p65 in the Inhibition of Lipopolysaccharide-Induced Shock

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A Role for NF-κB Subunits p50 and p65 in the Inhibition of Lipopolysaccharide-Induced Shock

Content Provider	Scilit
Author	Gadjeva, Mihaela Tomczak, Michal F. Zhang, Ming Wang, Yan Yan Dull, Karen Rogers, Arlin B. Erdman, Susan E. Fox, James G. Carroll, Michael Horwitz, Bruce H.
Copyright Year	2004
Description	To evaluate the possibility that NF-κB subunits p50 and p65 have a role in limiting the systemic inflammatory response induced by endotoxin, we compared the susceptibility of wild-type (WT), $p65^{+/−}$, $p50^{−/−}$, and $p50^{−/−}p65^{+/−}$ (3X) mice to LPS-induced shock. Interestingly, whereas $p65^{+/−}$ mice were no more sensitive than WT mice to LPS-induced shock, 3X mice were exquisitely sensitive to the toxic effects of LPS. Mice lacking p50 alone displayed an intermediate phenotype. Sensitivity to LPS was a property of the innate immune system and was characterized by elevated circulating levels of TNF in both $p50^{−/−}$ and 3X mice. The ability of LPS to induce shock depended upon TNF, and 3X mice were significantly more sensitive to the toxic effects of TNF than were p50-deficient mice. The expression of several LPS-inducible proinflammatory genes, including IFN-γ, was significantly higher within the spleens of $p50^{−/−}$ mice than in the spleens of WT mice, and interestingly, the expression of IFN-γ was augmented still further within the spleens of 3X mice. These results demonstrate that NF-κB subunits p50 and p65 have critical inhibitory functions during the systemic response to LPS and raise the possibility that these functions could be essential in preventing mortality associated with systemic inflammatory response syndromes.
Ending Page	5793
Page Count	8
Starting Page	5786
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.173.9.5786
Journal	The Journal of Immunology
Issue Number	9
Volume Number	173
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2004-11-01
Access Restriction	Open
Subject Keyword	Innate Immune Wt Mice Systemic Inflammatory Response
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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