NDLI: Critical Role of CD4 Help in CD154 Blockade-Resistant Memory CD8 T Cell Activation and Allograft Rejection in Sensitized Recipients

Content Provider	Scilit
Author	Wu, Zheng Wang, Yue Gao, Feng Shen, Xiuda Zhai, Yuan Kupiec-Weglinski, Jerzy W.
Copyright Year	2008
Description	Allograft rejection in sensitized recipients remains the major problem in clinical organ transplantation. We have developed a donor-type skin-sensitized mouse cardiac allograft model (BALB/c→C57BL/6) in which both rejection (30 days), paralleled by selective target gene depression at the graft site. These results provide the rationale to probe potential synergy of adjunctive therapy targeting CD4 and CD154 to overcome graft rejection in sensitized recipients.
Ending Page	1102
Page Count	7
Starting Page	1096
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.181.2.1096
Alternate Webpage(s)	http://www.jimmunol.org/content/181/2/1096.full.pdf
Journal	The Journal of Immunology
Issue Number	2
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-07-15
Access Restriction	Open
Subject Keyword	Sensitized Recipients Rejection in Sensitized
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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