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Pathogen-Specific CD8 T Cell Responses Are Directly Inhibited by IL-10
| Content Provider | Scilit |
|---|---|
| Author | Biswas, Partha Sarathi Pedicord, Virginia Ploss, Alexander Menet, Ewa Leiner, Ingrid Pamer, Eric G. |
| Copyright Year | 2007 |
| Description | Regulation of CD8 T cell expansion and contraction is essential for successful immune defense against intracellular pathogens. IL-10 is a regulatory cytokine that can restrict T cell responses by inhibiting APC functions. IL-10, however, can also have direct effects on T cells. Although blockade or genetic deletion of IL-10 enhances T cell-mediated resistance to infections, the extent to which IL-10 limits in vivo APC function or T cell activation/proliferation remains unknown. Herein, we demonstrate that primary and memory CD8 T cell responses following Listeria monocytogenes infection are enhanced by the absence of IL-10. Surface expression of the IL-10R is transiently up-regulated on CD8 T cells following activation, suggesting that activated T cells can respond to IL-10 directly. Consistent with this notion, CD8 T cells lacking IL-10R2 underwent greater expansion than wild-type T cells upon L. monocytogenes infection. The absence of IL-10R2 on APCs, in contrast, did not enhance T cell responses following infection. Our studies demonstrate that IL-10 produced during bacterial infection directly limits expansion of pathogen-specific CD8 T cells and reveal an extrinsic regulatory mechanism that modulates the magnitude of memory T cell responses. |
| Ending Page | 4528 |
| Page Count | 9 |
| Starting Page | 4520 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.179.7.4520 |
| Journal | The Journal of Immunology |
| Issue Number | 7 |
| Volume Number | 179 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2007-10-01 |
| Access Restriction | Open |
| Subject Keyword | Cell Responses Cd8 T Cells Pathogen Specific Cd8 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
